Erectile dysfunction drugs and skin cancer — should you worry?
By health.harvard.edu
A study published in JAMA Internal Medicine in 2014 found that men who used the erection-enhancing drug sildenafil (Viagra) were 84% more likely to develop melanoma, the most dangerous form of skin cancer, over a period of 10 years.
That finding makes for an attention-grabbing headline. But it’s also what I would call a true lie: a scientifically correct statement that could easily be misunderstood to mean “that little blue pill gives you deadly skin cancer.”
Here are two truths about this work that you need to know. 1) This study does not show that Viagra causes skin cancer. Instead, it shows that in a large group of men, those who said they used Viagra ended up being diagnosed more often with melanoma than those who didn’t use this drug. The study shows a connection, not a cause. 2). Even if Viagra does promote melanoma, the absolute increase is small.
I asked an expert in melanoma and skin cancer risk at Harvard-affiliated Massachusetts General Hospital, Dr. Hensin Tsao, what he thought of the study. He kindly shot back an email offering his perspective: “This is certainly a provocative study and warrants more careful replication. Several factors need to be considered.” Allow me to translate: The devil is in the details. The study is interesting but it does not mean that men should be worried—yet—that Viagra causes melanoma.
But they should definitely be worried about melanoma.
Risky business
The study grew out of laboratory research on how Viagra acts on cell-to-cell signaling pathways. This work demonstrated that the drug mimics key parts of a process that lets melanoma cells spread to other parts of the body. Skin cancer that spreads (metastasizes) is hard to control and can end in death.
To explore whether Viagra might have the same effect on melanoma in humans, a team of researchers looked at data collected from men taking part in the Health Professionals’ Follow-up Study, a project based at Harvard that began in 1986. The men filled out health and lifestyle questionnaires every two years. The questionnaire started asking men about use of erectile dysfunction drugs in 2000. In that year, 1,618 men reported having ever used Viagra.
Over the next decade, among the 29,929 men who said they had never used Viagra, 128 developed melanoma. Among the 1,618 Viagra users, 14 developed melanoma. In other words, 4.3 of every 1,000 who didn’t take Viagra developed melanoma compared to 8.6 of every 1,000 men who took Viagra.
After statistical adjustments, the increase from 4.3 to 8.6 is the 84% increase in risk that many news reports focused on. Researchers call that the relative risk (one group compared to another). The absolute increase, 4.3 cases per 1,000 men, represents an increase of 0.43%.
Whether a similar connection might exist between other erectile dysfunction drugs and melanoma isn’t known. In 2000, when the study was started, Viagra was the only erectile dysfunction drug on the market. Tadalafil (Cialis) and vardenafil (Levitra) weren’t approved until 2003, while avanafil (Stendra) came on the market in 2012.
How risky is that business?
The raw numbers suggest that the risk for melanoma associated with Viagra is small—one of the factors that Dr. Tsao said “need to be considered” when weighing the significance of the study. It’s even smaller than what was reported in the study because not all of the 14 cancers in the Viagra group can be attributed to the drug. Many factors affect a man’s risk of melanoma—the most important of which are age and cumulative exposure to ultraviolet (UV) radiation.
Should you worry?
Should men who use Viagra worry about getting melanoma? Right now, no one can say. The relationship could be pure coincidence. Epidemiological studies like this one tell you only who is at the scene of the crime, not who done it. The findings of the JAMA Internal Medicine study need to be replicated in other groups of men before sounding any warning bells.
In the meantime, Dr. Tsao offers some urgent advice to men: Protect your skin from too much sun and have routine skin checks to identify melanoma and other types of skin cancer early, while they are still treatable.
That’s especially important for older men, who are at greater risk for developing melanoma and also at greater risk for dying from it. An estimated 76,000 Americans (more than half of them men) will be diagnosed with melanoma this year, and almost 10,000 will die from it.
In short, be afraid—but not of Viagra. Be concerned about getting too much sun and pay attention to weird-looking moles that could turn into metastatic cancer. Cover up when you go outside, and use a broad-spectrum sunscreen liberally when you do go out into the sun to work and play.
Source: http://www.health.harvard.edu/blog/erectile-dysfunction-drugs-skin-cancer-worry-201406057197
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Monday, May 11, 2026
Understanding LDL Cholesterol Elevation and When Atorvastatin Therapy Becomes Necessary
Elevated LDL cholesterol remains one of the most modifiable risk factors for heart attack and stroke, and millions of people worldwide manage their cardiovascular risk through a combination of lifestyle changes and lipid-lowering medication. Understanding the clinical reasoning behind cholesterol treatment decisions helps patients make informed choices about long-term management. Low-density lipoprotein particles deposit cholesterol inside arterial walls over time, contributing to atherosclerotic plaques that narrow blood flow and raise cardiovascular risk. The higher the LDL level and the longer it remains elevated, the greater the cumulative arterial damage. This process happens without symptoms, which is why routine lipid screening catches problems before events occur. Treatment guidelines from cardiology societies address when medication becomes appropriate. Patients who have already experienced a heart attack, stroke, or significant coronary disease begin statin therapy regardless of initial LDL level because reducing cardiovascular events in this population is well established. These high-risk patients typically need aggressive LDL reduction to targets below seventy milligrams per deciliter. Primary prevention patients, those who have not yet had a cardiovascular event, enter the treatment equation based on a combination of LDL level, age, blood pressure, smoking history, diabetes status, and family history. Cardiovascular risk calculators help providers estimate ten-year event risk and determine whether the expected benefit from statin therapy outweighs any potential downsides. Lifestyle modification represents the foundation of cholesterol management before and alongside medication. A heart-healthy diet low in saturated fat, elimination of trans fats, increased dietary fiber from vegetables and whole grains, regular aerobic exercise, and weight management can each reduce LDL measurably. When these changes are insufficient to reach an LDL target aligned with a patient's cardiovascular risk, medication adds the required additional reduction. Atorvastatin, marketed as Lipitor, is among the most prescribed statins worldwide due to its proven cardiovascular outcome data from major clinical trials. The ASCOT-LLA and TNT trials demonstrated significant reductions in cardiac events for high-risk patients treated with atorvastatin at standard doses. Discussing lipitor atorvastatin for cholesterol management with a qualified provider helps patients understand whether their LDL level and overall risk profile make them appropriate candidates for statin therapy. Monitoring after starting atorvastatin includes a lipid panel at four to twelve weeks to assess treatment response. Liver enzyme monitoring, previously required routinely, is now recommended only for patients with symptoms suggesting liver involvement. Most patients tolerate atorvastatin without significant side effects at standard doses. Understanding that cholesterol treatment typically continues long-term helps patients mentally prepare for this commitment. Stopping therapy without medical guidance usually allows LDL to return to pretreatment levels within weeks. For comprehensive guidance on cholesterol treatment principles and medication options, exploring cardiovascular risk and cholesterol treatment resources builds the foundation for confident, informed medical conversations.
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